If the following sentences were a paragraph,which would be the topic sentence?

Question:It may appear in the beginning of, within, at the end of, or two places in the paragraph.

1) depression can be bad for your heart and should not be ignored.
2) recent studies indicate that people who are depressed are three times more likely to die of heart disease than those who are not depressed.
3) It seems that depression can raise the level of stress in the body.
4) And stress triggers an increase in heart rate and blood pressure.
5) In addition, if you are depressed, you are less likely to exercise or eat rigth than people who are not depressed.
6) because depression can be harmful to your heart, it is important to pay attention to your emotional health.

Answers:
1 is the topic sentence and 6 is the concluding sentence (topic reworded). The others are supporting sentences.
Number 2
I'm thinking number six.
I vote for #6.
I would say 1.
Well it seems that your topic is Depression and it's effect on the heart so your first sentence is it.
Number 1 is the topic sentence, as the sentence describes what is going to be talked about in the rest of the paragraph. Although topic sentences normally appear as the first sentence, the topic sentence can also conclude the paragraph.

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